Short bowel syndrome (SBS) patients have a higher rate of central line associated bloodstream infection (CLABSI) than patients without intestinal failure (7.8 vs 1.3 per 1000 catheter days). SBS patients have a high incidence of gram-negative bacteremia, which is known to carry a high rate of morbidity and mortality. Prompt administration of antibiotics is crucial for successful management of patients with central line and fever. Our aim was to decrease the time to antibiotics in SBS patients with central line and fever in the emergency department (ED) by 50% by December of 2016.