Monthly Archives: August 2017

Question: A 75-year-old woman with celiac disease diagnosed 30 years ago who is not compliant with a gluten-free diet, and has gastroesophageal reflux disease and hypothyroidism, presented with gradually worsening abdominal distension, severe intermit… Continue reading →

Question: A 21-year-old man with a 3-year history of hematochezia presented to the gastroenterology department with drop bright red blood after defecation, which was aggravated after eating spicy foods. He denied any history of hepatitis. On physical e… Continue reading →

Question: A 51-year-old man was referred to our tertiary medical center for a 3-year history of intermittent abdominal pain, diarrhea, and associated nontender, nonitchy cutaneous erythema and swelling of his upper and lower extremities (Figure A) and … Continue reading →

This document presents the official recommendations of the American Gastroenterological Association (AGA) on therapeutic drug monitoring (TDM) in inflammatory bowel disease (IBD). The guideline was developed by the AGA’s Clinical Guidelines Committee… Continue reading →

Interactions between commensal microbes and the immune system are tightly regulated and maintain intestinal homeostasis, but little is known about these interactions in humans. We investigated responses of human CD4+ T cells to the intestinal microbiot… Continue reading →

The incidence of esophageal adenocarcinoma (EAC) has increased in many Western countries, and is higher in men than women. Some risk factors for EAC have been identified—mainly gastroesophageal reflux disease (GERD), Barrett’s esophagus, obesity, a… Continue reading →

Gastroesophageal reflux disease (GERD) is the most prevalent gastrointestinal disorder in the United States, and leads to substantial morbidity, though associated mortality is rare. The prevalence of GERD symptoms appeared to increase until 1999. Risk … Continue reading →

We performed a screen for genes whose expression correlates with invasiveness of esophageal squamous-cell carcinoma (ESCC) cells. We studied the effects of overexpression and knockdown of these genes in cell lines and expression levels in patient samples. Continue reading →

This study documents that BMI1 and MEL18 are required for colitis-associated cancer (CAC) development via regulating a novel REG3B-STAT3 signaling pathway. The findings may have wide implications for the prevention and treatment of CAC. Continue reading →

Chronic hepatitis affects phenotypes of innate and adaptive immune cells. Mucosal associated invariant T (MAIT) cells are enriched in the liver as compared to the blood, respond to intra-hepatic cytokines, and (via the semi-invariant T-cell receptor) t… Continue reading →