Daily Archives: September 1, 2017

Risk for Hepatocellular Carcinoma After Hepatitis C Virus Antiviral Therapy With Direct-acting Antivirals: Case Closed?

The development of direct-acting antivirals (DAAs) for the treatment of hepatitis C virus (HCV) infection was well-received by patients and physicians, as viral clearance is associated with improved liver-related and overall survivals.1,2 Despite this … Continue reading

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Covering the Cover

In a large cohort of patients with chronic hepatitis C infection, sustained virologic response after direct-acting antiviral therapy lowered, but did not eliminate, the risk of hepatocellular carcinoma. Continue reading

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Pediatric Liver Transplantation: An Asymmetrical War for Access to Livers

The United States has lead the way in developing organ-sharing algorithms with emphasis on reducing waiting-list mortality.1 Allocation based on the Model for End-stage Liver Disease score has been a revolutionary measure, not just for upholding the pr… Continue reading

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How to Maximize the Diagnostic Yield of Endoscopic Ultrasound-Guided Fine Needle Aspiration Biopsy

The first endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNA) was performed in 1991 for the diagnosis of mucinous cystadenoma of the pancreas.1 Since then, endoscopic ultrasound imaging has advanced with regard to the diagnosis of panc… Continue reading

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Is a Biosimilar Interchangeable With an Originator?

What’s in a name? That which we call a rose by any other name would smell as sweet.William Shakespeare, Romeo and Juliet (Act 2, Scene 2, Page 2) Continue reading

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Natural Course of Unusual Primary Liver Tumor

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Enhanced Reprocessing of Duodenoscopes: Is Doing More Better?

Although the potential for infections to be transmitted between patients due to inadequately reprocessed duodenoscopes was initially identified >30 years ago,1 several recent fatal outbreaks of carbapenem-resistant Enterobacteriaceae associated with duodenoscope-transmission have brought this issue worldwide attention.2-4 To date, up to 350 patients at 41 facilities may have acquired infections from contaminated duodenoscopes since 2010.5 Unlike previous instances of endoscope-related transmission of infections, no significant breaches in manufacturer-recommended reprocessing protocols were identified at the affected sites when reviewed by the Centers for Disease Control and Prevention and the device manufacturers. Continue reading

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The Perils of Competitive Speed Eating!

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Disparities in National Institutes of Health Funding Between Gastrointestinal Disorders

The National Institutes of Health (NIH) is the major funder of research in gastrointestinal (GI) diseases. The National Institute for Diabetes and Digestive and Kidney Diseases’ discretionary appropriation for fiscal 2016 is $1.818 billion of the ove… Continue reading

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An Unusual Case of Abdominal Pain

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