Monthly Archives: September 2017
Is a Biosimilar Interchangeable With an Originator?
What’s in a name? That which we call a rose by any other name would smell as sweet.William Shakespeare, Romeo and Juliet (Act 2, Scene 2, Page 2) Continue reading
Pediatric Liver Transplantation: An Asymmetrical War for Access to Livers
The United States has lead the way in developing organ-sharing algorithms with emphasis on reducing waiting-list mortality.1 Allocation based on the Model for End-stage Liver Disease score has been a revolutionary measure, not just for upholding the pr… Continue reading
Disparities in National Institutes of Health Funding Between Gastrointestinal Disorders
The National Institutes of Health (NIH) is the major funder of research in gastrointestinal (GI) diseases. The National Institute for Diabetes and Digestive and Kidney Diseases’ discretionary appropriation for fiscal 2016 is $1.818 billion of the ove… Continue reading
Easing Concerns About the Low FODMAP Diet in Patients With Irritable Bowel Syndrome
Dietary management makes sense in patients with irritable bowel syndrome, because food is a major inducer of symptoms, and dietary manipulation empowers patients to influence the outcome of their disorder. It is not surprising, therefore, that the arri… Continue reading
How to Maximize the Diagnostic Yield of Endoscopic Ultrasound-Guided Fine Needle Aspiration Biopsy
The first endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNA) was performed in 1991 for the diagnosis of mucinous cystadenoma of the pancreas.1 Since then, endoscopic ultrasound imaging has advanced with regard to the diagnosis of panc… Continue reading
ROCKing the Field of Intestinal Fibrosis or Between a ROCK and a Hard Place?
Intestinal fibrosis remains one of the largest clinical challenges in the field of inflammatory bowel diseases.1 More than one-half of the patients with Crohn’s disease develop clinically apparent fibrostenosis throughout their disease course, leadin… Continue reading
Progress in PD-1–based Immunotherapy: New Mechanistic Insight May Provide Expanded Hope for Application to Colon and Gastrointestinal Cancers
Kamphorst AO, Wieland A, Tahseen Nasti T, et al. Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent. Science 2017;355:1423-1427. Continue reading
Covering the Cover
In a large cohort of patients with chronic hepatitis C infection, sustained virologic response after direct-acting antiviral therapy lowered, but did not eliminate, the risk of hepatocellular carcinoma. Continue reading
Risk for Hepatocellular Carcinoma After Hepatitis C Virus Antiviral Therapy With Direct-acting Antivirals: Case Closed?
The development of direct-acting antivirals (DAAs) for the treatment of hepatitis C virus (HCV) infection was well-received by patients and physicians, as viral clearance is associated with improved liver-related and overall survivals.1,2 Despite this … Continue reading
Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease
Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease is a comprehensive review of the use of anti-tumor necrosis factor (TNF) therapy in patients with inflammatory bowel disease (IBD). The book includes a preface and 35 chapters, which can … Continue reading