Daily Archives: October 5, 2017
Liver MAIT Cells in Hepatitis C: Pathogenetic Role or Innocent Bystanders?
Mucosal-associated invariant T (MAIT) cells represent the largest innate T-cell subset that recognizes bacteria in humans. MAIT cells tend to accumulate at the site of bacterial infections, where they can recognize antigens derived from microorganisms … Continue reading
A Long-Lasting Dysphagia
Question: A 74-year-elderly woman was presented to the clinic to be treated for dysphagia, which had persisted for more than 5 years. Previously, repetitive botulinum injections for suspected hypercontractile esophagus had been implemented in an extern… Continue reading
Endoscopic Ultrasound-Guided Pancreatic Cyst Ablation: More Peril Than Promise?
Pancreatic cysts are frequently encountered in clinical practice. They are typically asymptomatic and detected incidentally on cross-sectional abdominal imaging obtained for nonpancreatic indications. The prevalence of pancreatic cysts increases with a… Continue reading
Exam 3: BRCA1-Associated Protein Increases Invasiveness of Esophageal Squamous Cell Carcinoma
Exam 2: Superficial Esophageal Mucosal Afferent Nerves May Contribute to Reflux Hypersensitivity in Non-Erosive Reflux Disease
A 45-Year-Old Man With Recurrent Nausea, Vomiting, and Abdominal Distension
Question: A 45-year-old African American man with end-stage renal disease secondary to polycystic kidney disease, on peritoneal dialysis for the last 15 years, presented with worsening of nausea, vomiting, and abdominal distension, associated with a 20… Continue reading
A 45-Year-Old Man With Recurrent Nausea, Vomiting, and Abdominal Distension
Question: A 45-year-old African American man with end-stage renal disease secondary to polycystic kidney disease, on peritoneal dialysis for the last 15 years, presented with worsening of nausea, vomiting, and abdominal distension, associated with a 20… Continue reading
Multiple Openings in the Anterior Abdominal Wall Draining Pus for a Decade
Question: A 48-year-old man presented with persistent pus discharge from multiple openings in left inguinal region for the last 10 years (Figure A). He had undergone surgery (exploratory laparotomy) twice in the last 8 years with no relief. There was n… Continue reading
MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients from Ethanol-induced Liver Disease
Chronic, excessive alcohol consumption leads to alcoholic liver disease (ALD) characterized by steatosis, inflammation, and eventually cirrhosis. The hepatocyte specific microRNA 122 (MIR122) regulates hepatocyte differentiation and metabolism. We inve… Continue reading
Double-Bubble Sign in an Adult Patient
Question: A 64-year-old man with a history of cholelithiasis presented to the emergency department with intermittent epigastric pain followed by postprandial vomiting for 2 days. The patient began to have acute epigastric pain 2 days ago, which was des… Continue reading