Monthly Archives: October 2017
Insights into the Pathophysiology of Esophageal Adenocarcinoma
Although researchers have identified genetic alterations that contribute to development of esophageal adenocarcinoma, we know little about features of patients or environmental factors that mediate progression of chronic acid biliary reflux to Barrett?… Continue reading
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Management of Patients With Adenocarcinoma or Squamous Cancer of The Esophagus
Esophageal cancer is characterized by the early and frequent metastasis. Surgery is the primary treatment for early-stage disease, whereas patients with patients with locally advanced disease receive peri-operative chemotherapy or chemoradiotherapy. Sq… Continue reading
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Pathophysiology of Gastroesophageal Reflux Disease
The pathogenesis of gastroesophageal reflux disease (GERD) is complex and involves changes in reflux exposure, epithelial resistance, and visceral sensitivity. The gastric refluxate is a noxious material that injures the esophagus and elicits symptoms…. Continue reading
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The Role of Anchoring in Working Up Diarrhea: A Practical Teaching Case
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DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome
We analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about pathogenesis. Continue reading
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Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System
The enteric nervous system (ENS) regulates gastrointestinal function via different subtypes of neurons, organized into fine-tuned neural circuits. It is not clear how cell diversity is created within the embryonic ENS—information required for develop… Continue reading
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MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors
B cells infiltrate tumors but little is known about how they affect tumor growth and progression. microRNA15A (MIR15A or miRNA15A) and microRNA16-1 (MIR16-1 or miRNA16-1) regulate cell proliferation, apoptosis and drug resistance. We investigated their… Continue reading
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Low Rates of Gastrointestinal and non-Gastrointestinal Complications for Screening or Surveillance Colonoscopies in a Population-based Study
The full spectrum of serious non-gastrointestinal (non-GI) post-colonoscopy complications has not been well characterized. We analyzed rates of and factors associated with adverse post-colonoscopy GI and non-GI events (cardiovascular, pulmonary, or inf… Continue reading
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Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System
The enteric nervous system (ENS) regulates gastrointestinal function via different subtypes of neurons, organized into fine-tuned neural circuits. It is not clear how cell diversity is created within the embryonic ENS—information required for develop… Continue reading
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Low Rates of Gastrointestinal and non-Gastrointestinal Complications for Screening or Surveillance Colonoscopies in a Population-based Study
The full spectrum of serious non-gastrointestinal (non-GI) post-colonoscopy complications has not been well characterized. We analyzed rates of and factors associated with adverse post-colonoscopy GI and non-GI events (cardiovascular, pulmonary, or inf… Continue reading
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