Daily Archives: November 3, 2017

We read with interest the above article by Goldberg et al that described patients from 4 Ashkenazi Jewish families with a 40-kb duplication upstream of GREM1.1 The authors presented the clinical manifestation of these patients classified as hereditary… Continue reading →

Serrated polyposis syndrome (SPS) is perhaps the least understood and most prevalent polyposis syndrome currently known and is associated with an increased prevalence of colorectal cancer (CRC).1,2 In screening populations, prevalence rates of up to 1:… Continue reading →

Kaminski et al1 used feedback and quality benchmark indicators to improve colonoscopy performance and happily they succeeded. They confirmed that increasing the rate of adenoma detection (RAD) is associated with a reduced risk of colorectal cancer and death.2 Nevertheless, their findings may not be generalizable to other settings. First, they should provide the rationale how they divided ADR into quintiles of ≤11.21%, 11.22% to 15.10%, 15.11% to 19.17%, 19.18% to 24.56%, and >24.56%; these divisions seem arbitrary and very different from their previous reports. Continue reading →

Direct acting antiviral agents have revolutionized the treatment of chronic infection with hepatitis C virus (HCV), but further improvements are needed to meet the public health goal of controlling HCV worldwide. Shortened courses of therapy might redu… Continue reading →