Monthly Archives: November 2017
HLA-DQ–Gluten Tetramer Blood Test Accurately Identifies Patients With and Without Celiac Disease in Absence of Gluten Consumption
Celiac disease is characterized by HLA-DQ2/8-restricted responses of CD4+ T cells to cereal gluten proteins. A diagnosis of celiac disease based on serologic and histologic evidence and duodenal histology requires patients to be on gluten-containing di… Continue reading
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Germline Genetic Features of Young Individuals with Colorectal Cancer
The incidence of colorectal cancer (CRC) in individuals younger than 50 years old is increasing. We sought to ascertain the proportion of young CRC cases associated with genetic predisposition. Continue reading
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Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis
Paneth cell dysfunction causes deficiencies in intestinal C-type lectins and antimicrobial peptides, which leads to dysbiosis of the intestinal microbiota, alters the mucosal barrier, and promotes development of inflammatory bowel diseases. We investig… Continue reading
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Non-invasive Diagnosis of Pancreatic Cancer Through Detection of Volatile Organic Compounds in Urine
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The 75th Diamond Anniversary of Gastroenterology: 1943-2018
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The Sentinel Bleed
Question: A 60-year-old man with a past medical history significant for atrial fibrillation (AF) status post ablation in 2006 on warfarin, bicuspid aortic valve status post mechanical aortic valve replacement with subsequent elective surgical valve exp… Continue reading
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Portal Hypertension and Unexplained Diarrhea in an 80-year-old man
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No Increase in Risk of Acute Myocardial Infarction in Privately Insured Adults Prescribed Proton Pump Inhibitors vs Histamine-2 Receptor Antagonists (2002–2014)
Proton pump inhibitors (PPIs) are commonly used medications. Recent studies reported an increased risk of acute myocardial infarction (MI) in PPI users vs non-users. We evaluated MI risk associated with PPIs compared with histamine-2 receptor antagonis… Continue reading
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Population Health Management for Inflammatory Bowel Disease
Inflammatory bowel diseases (IBD) are chronic and impose significant, multi-dimensional burdens on patients and healthcare systems. The increasing prevalence of IBD will only worsen this problem globally—population health management (PHM) strategies … Continue reading
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Dense Mysterious Small Balls in the Abdomen
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