Monthly Archives: November 2017

Pre-clinical studies have shown aspirin to have anti-cancer properties and epidemiologic studies have associated aspirin use with longer survival times of patients with cancer. We studied 2 large cohorts to determine the association between aspirin use… Continue reading →

We sincerely appreciate the comments of Bleijenbert et al regarding our study. However, we would like to specify some of these comments. Bleijenbert et al point out potential differences in indications between serrated polyposis syndrome (SPS) and mu… Continue reading →

Question: A 34-year-old man with past medical history of human immunodeficiency virus (HIV) infection, presented to the hospital with complaints of dysphagia, epigastric abdominal pain, and watery diarrhea for last 2 months. This was accompanied by low… Continue reading →

Question: A 37-year-old white man with no past medical history was referred to our clinic for further evaluation of multiple incidental hepatic lesions. The patient initially presented to an outside hospital week prior for an episode of acute cholecyst… Continue reading →

Question: A 66-year-old man was admitted to the hospital owing to the presence of a pancreatic mass. His personal history and family history were unremarkable. There was no abnormality in serum tumor markers. An enhanced abdominal computed tomography s… Continue reading →

Question: A 44-year-old woman with a new diagnosis of cirrhosis likely as a result of alcohol abuse was admitted to the intensive care unit (ICU) with pneumonia and was intubated. That day she developed diarrhea as a result of Clostridium difficile inf… Continue reading →

Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new therapeutic agents are needed. We performed a screen to identify small molecule compounds that are active against CCAs. Levels of microRNA 21 (MIR21 or miRNA21) are increased in CCAs. We i… Continue reading →

Question: A 48-year-old Caucasian woman with congenital malrotation, juvenile diabetes, and prior en bloc small bowel and pancreas transplant in 2010 was admitted to our hospital with acute onset hypotension, fever, and lethargy that occurred during he… Continue reading →

We read with interest the above article by Goldberg et al that described patients from 4 Ashkenazi Jewish families with a 40-kb duplication upstream of GREM1.1 The authors presented the clinical manifestation of these patients classified as hereditary… Continue reading →

Serrated polyposis syndrome (SPS) is perhaps the least understood and most prevalent polyposis syndrome currently known and is associated with an increased prevalence of colorectal cancer (CRC).1,2 In screening populations, prevalence rates of up to 1:… Continue reading →