Daily Archives: December 21, 2017

This special issue of Gastroenterology provides in depth discussions of esophageal diseases with significant public health interest for which there have been substantial advances in recent years, including gastro-esophageal reflux disease, eosinophili… Continue reading →

Cytokinesis can fail during normal post-natal liver development, leading to polyploid hepatocytes. We investigated whether inhibiting cytokinesis in the liver; slows tumor growth without compromising the health of normal hepatocytes. We inhibited cytok… Continue reading →

Cell stress signaling pathways result in phosphorylation of the eukaryotic translation initiation factor 2 subunit alpha (EIF2S1 or EIF2A), which affects regulation of protein translation. Translation reprogramming mitigates stress by activating pathwa… Continue reading →

Inhibitors of the hepatitis C virus (HCV) NS5A protein are a key component of effective treatment regimens, but the genetic heterogeneity of HCV has limited the efficacy of these agents and mutations lead to resistance. We directly compared the efficac… Continue reading →

Pancreatic ductal adenocarcinoma (PDAC) is characterized by activated pancreatic stellate cells (PSCs), abundance of extracellular matrix (ECM), and production of cytokines and chemokines. Galectin 3 (GAL3), a β galactoside-specific lectin, contribute… Continue reading →

Central neuromodulators (antidepressants, antipsychotics and other CNS targeted medications) are increasingly used for treatment of functional GI disorders (FGIDs), now recognized as disorders of gut-brain interaction. However, the available evidence a… Continue reading →