Daily Archives: January 18, 2018

With the success of immunotherapy in oncology for the past 5-10 years, there are also associated toxicities, including colitis. The current management strategy is mainly steroid, infliximab and/or vedolizumab based on small case reports and case series… Continue reading →

Crohn’s is an aggressive inflammatory bowel disease driven by interactions of unknown relative significance between the immune system, the microbiome, and the intervening intestinal epithelial barrier. Histopathology analyses and genome-wide associat… Continue reading →

Patients with fibrostenotic Crohn’s disease (CD) are commonly advised to avoid fiber during symptomatic episodes. Fiber intake modulates the intestinal microbiota composition. The influence of low fiber diets in patients with Crohn’s disease on the… Continue reading →

Inflammation triggers stem cell proliferation to repair the tissue damage, while abnormal gene expression can transform temporary hyperplasia into a fertile ground for tumorigenesis. We investigated the role and mechanism of microRNA miR-34a deficiency… Continue reading →

The generation of high-quality pilot data that leads to “go/no-go decisions” regarding new or repurposed drugs is often problematic, particularly with a high placebo response rate. In short duration trials, pharmacodynamic (PD) biomarkers can demon… Continue reading →

Fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection. To provide effective FMT protocol for ulcerative colitis (UC) has been desired. We previously reported that the combination therapy with mul… Continue reading →

A comorbidity of inflammatory bowel disease (IBD) is inflammation-induced bone loss characterized by elevated bone resorption and decreased bone formation. Fracture incidence is resultantly elevated. Using a TNBS rat model, we have found osteocytes, ce… Continue reading →

Existing data regarding the association between inflammatory bowel disease (IBD) and pregnancy outcomes is lacking in Korea. Continue reading →

Exercise has been shown to be safe and have symptom reduction in patients with inflammatory bowel disease (IBD). However, there has been inconsistent incorporation of physical activity in IBD management. This study evaluated physician awareness of exer… Continue reading →

Crohn’s Disease and ulcerative colitis present distinct characteristics, one being the expansion of mesenteric adipose tissue (MAT) surrounding the inflamed intestinal tract (“creeping fat”-CF), which is typical for CD and absent in UC. To-date, … Continue reading →