Daily Archives: January 18, 2018

This study was conducted to explore the association of endocytoscopy (EC) findings with inflammatory activity and clinical course in ulcerative colitis (UC). EC was conducted for mild to moderate UC 32 cases from January 2010 to August 2016. The EC fin… Continue reading →

A 26-year-old male with ulcerative pancolitis diagnosed 11 years before, with episodes of severe colitis and steroid-dependent disease, was initially managed with azathioprine and infliximab, latter switched to adalimumab due to an infusion reaction. F… Continue reading →

Clostridium difficile infection (CDI) is recognized as a major clinical complication in patients with ulcerative colitis (UC). However, the mechanism associated with increased susceptibility to C. difficile in UC patients remains poorly understood. Giv… Continue reading →

Barrier function of colonic epithelium is compromised in IBD patients and contributes to colonic inflammation. Previously, we showed that aftiphilin (AFTPH) is significantly downregulated in colonic biopsies from UC patients and involved in receptor re… Continue reading →

While FOXP3+ regulatory T cell (Treg) dysfunction has been linked to human inflammatory bowel disease (IBD), molecular mechanisms for disease pathophysiology are unclear. The transcription factor FOXP3 via histone methyltransferase EZH2 suppresses infl… Continue reading →

Recently, genetic variants conferring risk for IBD were fine-mapped to single variant resolution. Eight of these causal variants resulted in amino acid substitutions while ten were non-coding. The mechanism by which these non-coding causal variants con… Continue reading →

Loss-of-function mutations in the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene locus increase IBD susceptibility. We reported that PTPN2 knockdown (PTPN2-KD) in intestinal epithelial cells (IECs): (i) increased IFN-g activation of STAT… Continue reading →

Practicing patient-centric care by incorporating patient preferences in IBD care is increasingly recognized to be important. However, existing IBD disease activity measures do not incorporate patient perspective. Here, we describe the development of a … Continue reading →

Distinguishing between inflamed Meckel’s diverticulum (MD) and ileal Crohn’s disease (CD) can be challenging. We present a case of suspected MD in a patient with CD. Continue reading →