Daily Archives: January 18, 2018

Increased Th1/Th17 immune response is a hallmark of Crohn’s Disease (CD) Immunopathogenesis. CD90+ (myo)fibroblasts (CMF) are an abundant cells in colonic mucosa contributing to the mucosal tolerance via suppression of Th1 cell activity through PD-L1… Continue reading →

There has been limited investigation of pediatric patients with medically refractory inflammatory bowel disease (IBD) who have been treated with biologic agents and undergo operative management. Adult studies have been mixed. This study compares patien… Continue reading →

Pro-inflammatory macrophages (Mø) are crucial for onset of intestinal inflammation, and defects that enable persistence of these cells may contribute to inflammatory bowel disease. We recently showed that the ErbB4 receptor tyrosine kinase is induced … Continue reading →

Few studies have examined the association between severity of inflammatory bowel disease (IBD) and humanistic burden. The current study examined the association between IBD severity and health-related quality of life (HRQoL). Continue reading →

A diet high in animal meat and fat has been linked to an increased risk for ulcerative colitis (UC) and high meat intake increases the likelihood of UC flares. Despite these correlations, there has never been a controlled, prospective study to investig… Continue reading →

Patients frequently have questions about how IBD influences pregnancy. Both patients and providers should have a clear understanding of the risks of IBD and the risks and benefits of continuing IBD treatments in the pregnant patient. We sought to asses… Continue reading →

Regulatory T cells (Tregs) isolated from IBD patients function properly ex vivo, but are unable to restrain chronic inflammation in situ. The goal of this project is to investigate the mechanism(s) by which 17-beta estradiol (estrogen, E2) contributes … Continue reading →

Among pediatric patients with Crohn disease (CD), the variation in treatment of perianal complications (PaC) has not been characterized. The presence of PaC at CD diagnosis predicts more aggressive CD. If introduced early, steroid sparing medical thera… Continue reading →

Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis (UC), affect more than 1 million people in the United States. Lysophosphatidic acid (LPA) is known to be a regulator of inflammation as well as governor of vascular str… Continue reading →

Management of inflammatory bowel disease (IBD) remains a clinical challenge in patients with active cancer. Observational data have shown that treatment modification is made for either IBD and/or cancer once the diagnosis of cancer is made in such pati… Continue reading →