Daily Archives: January 19, 2018
Endoscopy Examination Time: Longer Is Really Better?
I read with interest the article by Park et al1 regarding the observation time of esophagogastroduodenoscopy (EGD) examination. In this retrospective study, the authors showed that slow endoscopists could detect neoplasms in 0.28% of patients as compa… Continue reading
A Rare Cause of Chronic Anemia and Recurrent Bowel Obstruction
Question: A 12-year-old boy presented with a history of iron deficiency anemia for which he had taken oral iron supplementation for 2 years. He also complained of intermittent right hip pain in recent years. He had no weight loss, no prolonged fever… Continue reading
Interval Cancers in Colorectal Cancer Screening Programs
We read with great interest the paper by van der Vlugt et al.1 The interval colorectal cancers (I-CRCs) detected in subjects after multiple rounds of a screening program based on the fecal immunochemical test (FIT) are one of our main interests. Our … Continue reading
Ceragenin CSA13 Reduces Clostridium difficile Infection in Mice by Modulating the Intestinal Microbiome and Metabolites
Clostridium difficile induces intestinal inflammation by releasing toxins A and B. The antimicrobial compound cationic steroid antimicrobial 13 (CSA13) has been developed for treating gastrointestinal infections. The CSA13-Eudragit formulation can be g… Continue reading
Pancreatitis-induced Depletion of Syntaxin 2 Promotes Autophagy and Increases Basolateral Exocytosis
Pancreatic acinar cells are polarized epithelial cells that store enzymes required for digestion as inactive zymogens, tightly packed at the cell apex. Stimulation of acinar cells causes the zymogen granules to fuse with the apical membrane, and the ce… Continue reading
Hepatitis B Virus Infection and Hepatitis C Virus Treatment in a Large Cohort of Hepatitis C–Infected Patients in the United States
The rare emergence of hepatitis B virus (HBV) reactivation among hepatitis C virus (HCV)-infected patients receiving direct-acting antiviral (DAA) therapy raises questions about how many HCV-infected patients have active, past, or latent/occult HBV co-… Continue reading