Hypercalcemia has been described in patients with many granulomatous diseases. Elevated serum calcium levels in the setting of granulomatous disease are caused by unregulated production of 1,25-dihydroxyvitamin D by activated macrophages. More commonly, Crohn’s disease is associated with hypocalcemia caused by vitamin D deficiency resulting from ileal resection and malabsorption of fat-soluble vitamins. Here we present a case of sever hypercalcemia in a patient with Crohn’s disease secondary to elevated 1,25-Dihydroxyvitamin D.