Inflammatory Bowel Diseases (IBD) are characterized by upregulation of Interferon-gamma (IFN-γ). Recently we showed that IFN-γ blockade by a specific antibody in Dextran Sodium Sulfate (DSS)-colitis mouse model results in increased angiogenesis and reduced vessel permeability(1). The aim of the present project was to validate the specific contribution of vascular effects of IFN-γ to the pathogenesis of IBD.