Inflammatory bowel disease (IBD) comprises primarily 2 disorders: ulcerative colitis (UC) and Crohn’s disease (CD). Most biomarkers used are not disease specific, but reflect generalized inflammation. The Aim of the work is to identify plasma proteomic profiles of UC cases and correlating this profile with the other diagnostic markers and activity of the disease. We performed a study with 70 plasma samples collected from patients classified in 2 groups (37 UC, 33 healthy controls) according to accredited criteria.