Colorectal cancer (CRC) risk in patients with inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC) is increased compared to the general population. The combination of IBD and PSC is associated with an increased risk for dysplasia and CRC following orthotopic liver transplant (OLT) for PSC. Considering the importance of surveillance colonoscopy, we evaluated PSC patients following OLT for the incidence of dysplasia/CRC.