Monthly Archives: January 2018

High levels of patient activation, defined as having the knowledge, skills, and confidence to effectively manage one’s care, has been associated with improved outcomes in many chronic conditions. We sought to evaluate the association between patient … Continue reading →

In Crohn’s disease (CD), disease severity is categorized by the Montreal classification. More complicated (stricturing and/or penetrating) disease is associated with poor quality of life. Our aim was to identify clinical, serological, and genetic fac… Continue reading →

Though pharmacokinetic studies suggest accelerated biologic drug clearance with increasing body weight, evidence of obesity’s impact on clinical outcomes in biologic-treated patients with ulcerative colitis (UC) is inconsistent. Hence, we evaluated t… Continue reading →

Cardiovascular associations of Crohn’s Disease (CD) are rare and include valvular heart disease, aortitis and aneurysm. We report an 11 year old with thoracic aortitis and aneurysm found during initial presentation of CD. Continue reading →

To assess whether obesity may affect natural history of inflammatory bowel diseases (IBD), we conducted an individual participant data (IPD) pooled analysis of placebo arms, using data from clinical trials of infliximab in IBD, using the Yale Open Data… Continue reading →

The incidence of Clostridium difficile infection (CDI) has been rising and its occurrence in Inflammatory Bowel Disease (IBD) is higher than the general population, yet there is no treatment protocol in these patients. Our study’s goal was to determine… Continue reading →

Nursing staff within a GI practice can coordinate care around IBD quality measures by checking for bone loss related to corticosteroid use, providing smoking cessation counseling, performing TB & HBV testing prior to initiating biologics, & ensuring that patients receive appropriate vaccinations. Studies continue to demonstrate care gaps around these measures. In 2016, the Postgraduate Institute for Medicine and MCM Education developed a Quality Improvement (QI) educational pilot program. This program was supported by an independent educational grant provided by Takeda Pharmaceuticals U.S.A., Inc. Continue reading →

Children with acute severe ulcerative colitis (ASC) often require hospitalization. Colectomy is needed for medically intractable disease. Patients often undergo endoscopy to exclude opportunistic infections and assess disease severity and extent. There… Continue reading →

While the effects of biologic agents on post-operative outcomes in Crohn’s disease patients is well-established, the effects on intra-operative variables including blood loss, operative time and length of small bowel resection remains to be determined. Continue reading →

Sprouty (SPRY), endogenous suppressor of receptor tyrosine kinase signaling is reported to be tumor suppressor in various cancers, whereas we demonstrated that SPRY2 illustrates tumor promoting characteristics in colorectal cancer (CRC) [Oncogene, 2016… Continue reading →