Monthly Archives: January 2018

Few studies have examined the association between severity of inflammatory bowel disease (IBD) and humanistic burden. The current study examined the association between IBD severity and health-related quality of life (HRQoL). Continue reading →

A diet high in animal meat and fat has been linked to an increased risk for ulcerative colitis (UC) and high meat intake increases the likelihood of UC flares. Despite these correlations, there has never been a controlled, prospective study to investig… Continue reading →

Patients frequently have questions about how IBD influences pregnancy. Both patients and providers should have a clear understanding of the risks of IBD and the risks and benefits of continuing IBD treatments in the pregnant patient. We sought to asses… Continue reading →

Regulatory T cells (Tregs) isolated from IBD patients function properly ex vivo, but are unable to restrain chronic inflammation in situ. The goal of this project is to investigate the mechanism(s) by which 17-beta estradiol (estrogen, E2) contributes … Continue reading →

Among pediatric patients with Crohn disease (CD), the variation in treatment of perianal complications (PaC) has not been characterized. The presence of PaC at CD diagnosis predicts more aggressive CD. If introduced early, steroid sparing medical thera… Continue reading →

Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis (UC), affect more than 1 million people in the United States. Lysophosphatidic acid (LPA) is known to be a regulator of inflammation as well as governor of vascular str… Continue reading →

Management of inflammatory bowel disease (IBD) remains a clinical challenge in patients with active cancer. Observational data have shown that treatment modification is made for either IBD and/or cancer once the diagnosis of cancer is made in such pati… Continue reading →

Mycobacterium avium ssp. paratuberculosis (MAP) has been suspected to play a role in Crohn disease (CD) pathogenesis. Prior studies of MAP detection in dairy cows have been more extensively investigated, successfully detecting the organisms by culture … Continue reading →

Anti-TNFα agents increase risk of infections due to systemic immunosuppression. Vedolizumab (VDZ) inhibits adhesions of gut-specific lymphocytes and thus may carry a lower risk. However, its safety in patients with prior tuberculosis (TB) infection is… Continue reading →

Crohn’s disease (CD) presents as chronic and often progressive intestinal inflammation, but the contributing pathogenic mechanisms are unclear. Our goal was to identify underlying alterations in intestinal host cells that could contribute to the chro… Continue reading →