Monthly Archives: January 2018

Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) enhances neutrophil regulation of gut bacteria. Crohn’s Disease (CD) patients with reduced neutrophil GM-CSF signaling are more likely to experience stricturing complications requiring surgery… Continue reading →

Simultaneous analyses of peripheral and mucosal immune compartments can yield insight into the pathogenesis of mucosal-associated diseases. Although methods to preserve peripheral immune cells are well established, studies involving mucosal immune cell… Continue reading →

Studies have shown that physical activity has therapeutic effects on inflammatory bowel disease (IBD) by reducing disease activity, improving intestinal symptoms and positively impacting quality of life. In addition, exercise is helpful in offsetting p… Continue reading →

We have published data sets revealing the majority of FOXP3 gene targets in CD4+ lymphocytes isolated from Crohn’s lesions are significantly up-regulated. FOXP3 gene target status in the disease state is incongruent with FOXP3 and its associated comp… Continue reading →

For women with chronic inflammatory diseases, diagnosis and treatment initiation often overlap with peak reproductive years. High disease activity is associated with increased risk of pregnancy complications and adverse outcomes; disease control is imp… Continue reading →

Crohn’s disease treatment costs with certolizumab pegol (CZP) have been shown to be lower than infliximab (IFX), mainly due to lower CZP drug costs. Here, we examined the one-year (yr) all-cause healthcare resource utilization (HRU) and costs, incurr… Continue reading →

Data are emerging about the role of patient input on decision making for treatment of IBD. There are now multiple options for biologics when considering mechanism of action and means of administration. We sought to understand some of the disconnect bet… Continue reading →

We reported that increased endoplasmic reticulum (ER) stress signaling in subepithelial myofibroblasts (SEMF) isolated from patients with stricturing Crohn’s disease contributes to activation of TGF-β1 and fibrosis. Increased TGF-β1 results from in… Continue reading →

Inflammatory bowel disease (IBD) is a complex civilization disease and has a prevalence of up to 0.2% in the Asian countries. The disease preferentially manifests in the second and third decade of life. Oral soft tissue lesions can precede or occur con… Continue reading →

The enteric nervous system regulates gut reflexes. Our prior data show that enteric glia regulate the activity and survival of enteric neurons in health and disease through mechanisms that involve the release of mediators through connexin-43 (Cx43) hem… Continue reading →