Monthly Archives: January 2018

The pustular eruption of ulcerative colitis, also known as neutrophilic pustulosis, is a poorly defined, yet well-described extraintestinal manifestation of ulcerative colitis (UC), occurring in 1-6% of cases. Continue reading →

Although anti-TNFα antibody treatment has been used for definite or suspected intestinal Behcet disease (BD), the efficacy of the treatment remains elusive. Continue reading →

Very early-onset inflammatory bowel disease (VEO-IBD), defined by the onset of IBD before 6 years of age, is often associated with more severe and extensive disease than IBD in older patients. Some VEO-IBD cases have been linked to mutations in primary… Continue reading →

According to the previous researches, there are variable results after solid organ transplantation (SOT) in inflammatory bowel disease (IBD) patients. However, no published data has been found in Asia. We aim to analyze the clinical course and outcomes… Continue reading →

Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptibe host. Polymorphisms in the TNFSF15 locus link TNF-like ligand 1A (TL1A) with IBD, but the functional impact of TL1A in regulati… Continue reading →

Neutralizing Granulocyte-Macrophage Colony Stimulating Factor auto-antibodies (GMAb) suppress neutrophil extrinsic GM-CSF signaling and increase risk for stricturing behavior in Crohn’s Disease (CD). We aimed to define clinical, genomic, and function… Continue reading →

Immunosuppressives (IM) are often used as maintenance therapy to reduce the risk of relapse in patients with inflammatory bowel disease (IBD). Vedolizumab (VDZ), a humanized monoclonal antibody that selectively targets the α4β7 integrin, has been app… Continue reading →

Anti-tumor necrosis factor (anti-TNF) medications are effective in controlling chronic inflammatory diseases, but information about pregnancy outcomes is still limited. Certolizumab pegol (CZP), a PEGylated, Fc-free anti-TNF approved for treatment of C… Continue reading →

Ulcerative colitis (UC) is associated with many extraintestinal manifestations including dermatologic and hematologic involvement. Thrombotic cutaneous gangrene (TCG) is a rare complication with potentially poor prognosis, often needing colectomy in ad… Continue reading →

Neutrophil (PMN) migration across the intestinal mucosa correlates with disease flares in individuals with IBD. Despite this correlation, molecular events regulating PMN transepithelial migration (TEpM) are still elusive. However, it is clear that the … Continue reading →