Monthly Archives: January 2018

Immune-checkpoint inhibitors (ICI) had made good success in in many cancer types for the past 5-10 years, meanwhile, ICI also lead to serious complications e.g. colitis. The management strategy involves high dose steroid with known significant side eff… Continue reading →

Immunotherapy enhances T cell’s action on tumor cells by inhibiting T cell inactivation. However, upregulation of T cells can lead to immunotherapy-induced colitis in which lymphocytic colitis (LC) pattern has been less frequently described. We prese… Continue reading →

Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare intractable disease characterized by persistent anemia and hypoproteinemia due to multiple small intestinal ulcers. Recently, we identified that the disease is caused by loss-of-function… Continue reading →

Pediatric patients with inflammatory bowel diseases (IBD) are at increased risk for poor psychosocial outcomes, including body image dissatisfaction (BID). We aimed to determine the prevalence and risk factors for BID in CCFA Partners Kids & Teens cohort. Continue reading →

Crohn’s disease (CD) and ulcerative colitis (UC) are the two major diseases that make up the inflammatory bowel disease (IBD). Studies indicate that several genes, in addition to those involved in the modulation of the immune response, are differential… Continue reading →

Crohn’s disease (CD) and ulcerative colitis (UC) are costly conditions that require life-long disease management. Both conditions can first present at any age, but it is unknown how healthcare costs differ according to the age at first diagnosis. Continue reading →

Inflammatory bowel disease (IBD) comprises primarily 2 disorders: ulcerative colitis (UC) and Crohn’s disease (CD). Most biomarkers used are not disease specific, but reflect generalized inflammation. The Aim of the work is to identify plasma proteomic… Continue reading →

Apoptotic bodies can be found to be marginally increased in untreated IBD. However, the presence of more than 6 apoptotic bodies per 10 contiguous crypts warrants further investigation. Apoptotic enteropathy (AE) has been described in different conditi… Continue reading →

Inflammatory bowel disease (IBD) is a complex disorder that is associated with significant morbidity. While many advances have been made in the recent past with new diagnostic and therapeutic tools, a deeper understanding of its basic pathophysiology i… Continue reading →

The prevention of the recurrence of Crohn’s disease (CD) after ileo-cecal resection remains difficult. Continue reading →