Monthly Archives: January 2018

Depression occurs in up to 21% of IBD patients and is associated with increased healthcare costs. Antidepressants (AD), used by nearly 29% of IBD patients, target stress and depression, functional intestinal and somatic symptoms. IBD-related perception… Continue reading →

Crohn’s disease (CD) patients are often colonized by adherent-invasive Escherichia coli (AIEC). Although the colonization by AIEC is known to contribute to the pathogenesis of CD, the mechanisms by which AIEC thrives within the inflamed intestine in CD… Continue reading →

GI infections (e.g. C. difficile and CMV) have been shown to worsen inflammatory bowel disease (IBD) activity and result in increased surgeries and hospitalizations. By conventional methods, only 10% of symptomatic IBD patients have detectable concurre… Continue reading →

Non-adherence to Infliximab (IFX) is associated with an increased risk of anti-drug antibodies which can lead to loss or response. We performed a retrospective review of IFX use among Veterans with inflammatory bowel disease (IBD) with the aim of quant… Continue reading →

p40 transactivates EGF receptor in intestinal epithelial cells, leading to protection of intestinal epithelial cells under the inflammatory condition. This study aimed to determine the effects of neonatal supplementation of p40 on intestinal developmen… Continue reading →

Clinically significant gastroduodenal involvement of Crohn’s disease (CD) is rare, affecting only 0.5-4% of CD patients. Gastric abscesses from CD are not well-documented in the existing literature. In this report, we present a rare case of CD compli… Continue reading →

To assess whether obesity may affect response to infliximab, we conducted an individual participant data (IPD) pooled analysis using data from clinical trials of infliximab in inflammatory bowel diseases (IBD), using the Yale Open Data Access (YODA) P… Continue reading →

Crohn’s disease (CD) is a chronic inflammatory gastrointestinal (GI) disorder that may involve any site of the GI tract. CD is characterized by intestinal and extra intestinal manifestations. Symptoms include persistent diarrhea and pain. Pain sympto… Continue reading →

Inflammation plays a role in the development of atrial fibrillation (AF). Thus, inflammatory bowel disease (IBD) may increase the risk of AF. Elevated Proinflammatory markers such as interleukin (IL)-6 in IBD have been closely associated with AF. Continue reading →

Ulcerative colitis (UC), a chronic gastrointestinal disease, presents during one’s most productive years. The primary symptoms of UC are well known, however, similarities and differences of lived experiences in adults and adolescents are not well cha… Continue reading →