Monthly Archives: January 2018

Overexpression of Dual oxidase 2 (Duox2) occurs as an early event in both human inflammatory bowel disease and mouse models of colitis, and has been associated with dysbiosis. We have previously shown that mice bearing constitutive activation of toll-l… Continue reading →

IBD is driven by excessive inflammation involving reciprocal interactions between innate and adaptive immune cells. To better understand how innate immunity contributes to IBD, colitis models that occur in the absence of adaptive immunity are needed. Continue reading →

Smoking is a well-known risk factor for Crohn’s disease (CD) onset and aggressive disease course in the Western population. However, previous studies imply that smoking was not associated with an increased risk for CD onset in Asian populations. Ther… Continue reading →

Lymphocytes are key mediators of inflammation and IBD, including ulcerative colitis (UC). GPR15 is a chemoattractant receptor for lymphocyte homing to the colon and is implicated in mouse models of colitis. It is expressed by subsets of CD4 and CD8 eff… Continue reading →

Opioids are commonly prescribed for temporary pain relief among individuals with inflammatory bowel disease (IBD); however, the efficacy of opioids for managing chronic pain is limited and risk of adverse effects is high. Emerging evidence demonstrates… Continue reading →

We performed a series of fecal microbiota transplantation (FMT) experiments to determine the functional persistence of human microbiota in our gnotobiotic (hGB) SAMP1/YitFc (SAMP) mouse model of Crohn’s disease (CD)-like ileitis. Continue reading →

Intestinal fibrosis is a pathological consequence of excessive myofibroblast proliferation and collagen deposition, frequently seen in Crohn’s disease. It is considered as an excessive repair response to injury and inflammation, but not always to be … Continue reading →

Diet may be an important factor in the natural history of Crohn’s disease (CD). We sought to determine whether exclusion of red and processed meats reduces the risk of CD relapse in a prospective randomized controlled trial. Continue reading →

An assortment of medical foods, formulated to be consumed or administered enterally under the supervision of a physician, have established roles in the management of Inflammatory Bowel Diseases (IBD) as adjunctive or stand-alone therapies. The internet… Continue reading →

The gut microbiota is suggested to play an important role in the pathogenesis of ulcerative colitis (UC). However, inter-individual and spatial variations hamper the identification of UC-related changes. We thus investigated paired mucosa-associated mi… Continue reading →