Daily Archives: February 5, 2018

The oral TLR7 agonist GS-9620 has anti-viral effects in woodchuck and chimpanzee models of chronic hepatitis B virus (HBV) infection. We investigated in a clinical trial the capacity of this agent to reconstitute protective immunity in patients with ch… Continue reading →

Somatic mutations have been found in the mitochondria in different types of cancer cells, but it is not clear whether these affect tumorigenesis or tumor progression. We analyzed mitochondrial genomes of 268 early-stage, resected pancreatic ductal aden… Continue reading →

Acute pancreatitis (AP) was the third most common gastrointestinal diagnosis in 2012, resulting in approximately 275,000 admissions and costing about $2.6 billion.1,2 It is also the most common pancreatic disease worldwide.3 The incidence is increasing, but death rates have actually decreased in recent years to <2%.1 However, ≥50% of the deaths occur within the first 2 weeks of diagnosis.4,5 The recent revised Atlanta classification6 described mild (usually interstitial), moderately severe (local complications without persistent organ failure), and severe (persistent organ failure) AP subtypes. Continue reading →