Daily Archives: March 28, 2018
How to Incorporate Quality Improvement and Patient Safety Projects in Your Training
Engaging physicians in quality improvement (QI) and patient safety (PS) efforts has become increasingly central to creating efficient delivery systems and improving patient care. Fellowship training in gastroenterology offers a unique opportunity to de… Continue reading
Improved Diet Quality Associates With Reduction in Liver Fat—Particularly in Individuals With High Genetic Risk Scores for Nonalcoholic Fatty Liver Disease
Dietary modification has been recommended for treatment of nonalcoholic fatty liver disease (NAFLD), although it is not clear whether improving diet quality can prevent its development. We performed a prospective study to examine the association betwee… Continue reading
ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice
The AT-rich interaction domain 1A gene (ARID1A) encodes a protein that is part of the large ATP-dependent chromatin remodeling complex SWI/SNF and is frequently mutated in human pancreatic ductal adenocarcinomas (PDACs). We investigated the functions o… Continue reading
Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells
Little is known about how the immune system affects stem cell features of pancreatic cancer cells. Immune cells that produce interleukin 17 A (IL17A) in the chronically inflamed pancreas (chronic pancreatitis) contribute to PanIN initiation and progres… Continue reading
Learning the Art of Editing: A Year With the AGA Editorial Fellowship
Gastroenterology is the flagship journal of the American Gastroenterological Association (AGA) and is read widely by clinicians, researchers, and trainees in the field. The journal consistently publishes game-changing studies, which often refocus the l… Continue reading
Intestinal failure and aberrant lipid metabolism in patients with DGAT1 deficiency
Congenital diarrheal disorders are rare inherited intestinal disorders characterized by intractable, sometimes life-threatening, diarrhea and nutrient malabsorption; some have been associated with mutations in diacylglycerol-acyltransferase 1 (DGAT1), … Continue reading