Over the past three-quarters of a century, manuscripts published in Gastroenterology have had a substantial impact on our clinical recognition, understanding, and management of peptic ulcer disease (PUD), Helicobacter pylori, gastroesophageal reflux disease (GERD), Barrett’s esophagus, and eosinophilic esophagitis (EoE). This article highlights selected, highly cited works with overlapping themes of acid injury, chronic mucosal inflammation, and H pylori infection that are historically contextualized in Figures 1 and 2.