Monthly Archives: May 2018

We read with interest the article published by Debes et al.1 These investigators observed that, in patients with hepatitis C-related cirrhosis, the serum levels of inflammatory cytokines before treatment and their modification with direct-acting anti… Continue reading →

Question: We describe a 47-year-old man who has sex with men and is infected with the human immunodeficiency virus, which was diagnosed 6 years ago. He was also a hepatitis B carrier and has a history of gout. He had mucus passage during defecation f… Continue reading →

We read with high interest the paper by Hadjiliadis et al, who report a 5- to 10-fold increased risk of colon cancer in patients with cystic fibrosis (CF), and a 25 to 30 time greater in patients with CF after organ transplantation1; patients with CF … Continue reading →

We performed a meta-analysis of individual patient data from 11 randomized controlled trials comparing corticosteroids, pentoxifylline, or their combination in patients with severe alcoholic hepatitis. We compared the effects of the treatments on survi… Continue reading →

MAF bZIP transcription factor G (MAFG) is activated by the farnesoid X receptor (FXR) to repress bile acid synthesis. However, expression of MAFG increases during cholestatic liver injury in mice and in cholangiocarcinomas. MAFG interacts directly with… Continue reading →

The Julius Friedenwald Medal honors an individual who has made lifelong contributions to the field of gastroenterology and contributed significantly to the American Gastroenterological Association (AGA). This is the highest honor bestowed by the AGA, a… Continue reading →

Little is known about the natural course of nonalcoholic fatty liver disease (NAFLD) with advanced fibrosis. We describe long-term outcomes and evaluate the effects of clinical and histologic parameters on disease progression in patients with advanced … Continue reading →

As of December 27, 2017, the medical world is a different place. There is a void left by the departure of Dr Horatio Jinich. He was a great humanitarian: a superb physician, thinker, communicator, and medical expert. Continue reading →

The physical properties of the extracellular environment such as matrix composition and mechanics are key factors that determine cancer cell behavior.1,2 Stiffening matrix is a result of a complex multidirectional interplay between stromal cells such a… Continue reading →