The glucagon like peptide 1 (GLP1) is produced by L cells in the intestine, and agonists of the GLP1 receptor are effective in treatment of diabetes. Levels of GLP1 increase with numbers of L cells. Agents that increase numbers of L cell might therefore be developed for treatment of diabetes. Ras homolog family member A (RHOA) signaling via Rho associated coiled-coil containing protein kinases 1 and 2 (ROCK1, ROCK2) controls cell differentiation, but it is not clear if this pathway regulates enteroendocrine differentiation in the intestinal epithelium.