Monthly Archives: June 2018
Karijolich named 2018 Pew Biomedical Scholar
John Karijolich, PhD, assistant professor of Pathology, Microbiology, and Immunology at Vanderbilt University Medical Center, has been named a Pew Biomedical Scholar by The Pew Charitable Trusts. Continue reading
Chronic Abdominal Pain in a 47-year-old Woman
NFκB in Pancreatic Stellate Cells Reduces Infiltration of Tumors by Cytotoxic T Cells and Killing of Cancer Cells, via Upregulation of CXCL12
Immunotherapies are ineffective against pancreatic cancer. We investigated whether the activity of nuclear factor (NF)κB in pancreatic stromal cells contributes to an environment that suppresses anti-tumor immune response. Continue reading
Diet Modifies Colonic Microbiota and CD4+ T Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-cell Expression of Interleukin 23
Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota, and T cells in development and progression of colitis… Continue reading
Efficacy of Ustekinumab in Inducing Endoscopic Healing in Patients with Crohn’s Disease
We evaluated the ability of ustekinumab, a monoclonal antibody against the p40 subunit of interleukins 12 and 23, to induce endoscopic healing in patients with moderate to severe Crohn’s disease (CD). Continue reading