Daily Archives: July 5, 2018

Expression of CCR6 and CXCR6 by Gut-derived CD4+/CD8alpha+ T-regulatory Cells Which are Decreased in Blood Samples From Patients With Inflammatory Bowel Diseases

Faecalibacterium prausnitzii a member of the Clostridium IV group of the Firmicutes phylum that is abundant in the intestinal microbiota, has anti-inflammatory effects. The relative level of F prausnitzii is decreased in fecal samples from patients wit… Continue reading

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No Association Between Screening for Hepatocellular Carcinoma and Reduced Cancer-related Mortality in Patients with Cirrhosis

Screening patients with cirrhosis for hepatocellular carcinoma (HCC) has been recommended. We conducted a matched case–control study within the US Veterans Affairs (VA) healthcare system to determine whether screening by abdominal ultrasonography (US… Continue reading

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Covering the Cover

In 2 prospective cohorts, histologic grade of intestinal metaplasia before radiofrequency ablation for Barrett’s esophagus predicts recurrent neoplasia and can be used to determine surveillance intervals. Continue reading

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Ceramide: A Potential Activator of Immune Responses Against Tumors

Recently, Li et al1 have reported that vein injection of nanoliposome C6-ceramide, a cell membrane permeable form of ceramide, slows growth of liver tumors in mice, through suppressing tumor-associated macrophage functions and enhancing tumor antigen-… Continue reading

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Reply

Thank you for the first letter commenting on our paper. In a case of pulmonary arterial hypertension (PAH) occurring in patients with ulcerative colitis (UC) under indigo naturalis treatment, PAH was associated with patients with UC after using indigo … Continue reading

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CME Exam 2: Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis

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CME Exam 1: Development of Evidence Based Surveillance Intervals following Radiofrequency Ablation of Barrett’s Esophagus

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Possible Association of Phlebitis-Induced Colitis With Indigo Naturalis

We read with great interest the recent article by Naganuma et al.1 The authors showed a significant effect of indigo naturalis in treating patients with ulcerative colitis (UC) in a randomized, placebo-controlled trial. In their study, patients were randomly assigned to groups given a daily dose of 0.5, 1.0, or 2.0 g of indigo naturalis or placebo for 8 weeks. The proportion of patients with a clinical response at week 8 was significantly higher in the 0.5-g indigo naturalis group (69.6%; P = .0002), 1.0-g indigo naturalis group (75.0%; P = .0001), and 2.0-g indigo naturalis group (81.0%; P < .0001) than in the placebo group (13.6%). Continue reading

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