Daily Archives: July 28, 2018

Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis

Posted on July 28, 2018 by Gastroenterology Journal

Activating transcription factor 6 (ATF6) regulates endoplasmic reticulum stress. We studied whether ATF6 contributes to the development of colorectal cancer (CRC) using tissue from patients and transgenic mice. Continue reading →

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Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary Oleate

Posted on July 28, 2018 by Gastroenterology Journal

The enzyme stearoyl-coenzyme A desaturase 1 (SCD or SCD1) produces mono-unsaturated fatty acids by introducing double bonds into saturated bonds between carbons 9 and 10, with oleic acid as the main product. SCD1 is present in the intestinal epithelium… Continue reading →

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Routine molecular analysis for Lynch syndrome among adenomas or colorectal cancer within a national screening program

Posted on July 28, 2018 by Gastroenterology Journal

It is important to identify individuals with Lynch syndrome because surveillance programs can reduce their morbidity and mortality from colorectal cancer (CRC). We assessed the diagnostic yield of immunohistochemistry to detect Lynch syndrome in patien… Continue reading →

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Solute Carrier Organic Anion Transporter Family Member 3A1 is a Bile Acid Efflux Transporter in Cholestasis

Posted on July 28, 2018 by Gastroenterology Journal

Bile acid transporters maintain bile acid homeostasis. Little is known about the functions of some transporters in cholestasis or their regulatory mechanism. We investigated the hepatic expression of solute carrier organic anion transporter family memb… Continue reading →

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No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies

Posted on July 28, 2018 by Gastroenterology Journal

Patients with Lynch syndrome are at high risk for developing colorectal cancer (CRC). Regular colonoscopic surveillance is recommended, but there is no international consensus on the appropriate interval. We investigated whether shorter intervals are a… Continue reading →

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