Monthly Archives: July 2018
eStar changes and updates announced
eStar Thrive training continues
Thrive is a supplemental training program for eStar that is specifically tailored for outpatient clinicians. The program was launched in June with a set of pilot sessions and has since been expanded to continue through the rest of the summer. Continue reading
Simtuzumab Is Ineffective for Patients with Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis
Lysyl oxidase like 2 (LOXL2) contributes to fibrogenesis by catalyzing cross linkage of collagen. We evaluated the safety and efficacy of simtuzumab, a monoclonal antibody against LOXL2, in a phase 2b trial of patients with advanced fibrosis caused by … Continue reading
Prevalence of antibiotic resistance in Helicobacter pylori: a systematic review and meta-analysis in World Health Organization regions
In 2017, the World Health Organization (WHO) designated clarithromycin-resistant Helicobacter pylori a high priority for antibiotic research and development. However, there are no clear data on the global distribution of resistance or its clinical effe… Continue reading
An Inside View: AGA Advocacy Priorities
As Congress and the Trump administration struggle with efforts to reform the US health care system, we thought it would be timely to update you on the work AGA does in Washington, DC, to support the science and practice of gastroenterology. Continue reading
Inflammatory Bowel Disease: Diagnosis and Therapeutics 3rd edition
The incidence of inflammatory bowel diseases (IBD) is increasing globally, outpacing what genetic influences alone could instigate and implicating complex interactions with environmental factors including the gut microbiome in its elusive aetiology. We… Continue reading
Expression of CCR6 and CXCR6 by Gut-derived CD4+/CD8alpha+ T-regulatory Cells Which are Decreased in Blood Samples From Patients With Inflammatory Bowel Diseases
Faecalibacterium prausnitzii a member of the Clostridium IV group of the Firmicutes phylum that is abundant in the intestinal microbiota, has anti-inflammatory effects. The relative level of F prausnitzii is decreased in fecal samples from patients wit… Continue reading
No Association Between Screening for Hepatocellular Carcinoma and Reduced Cancer-related Mortality in Patients with Cirrhosis
Screening patients with cirrhosis for hepatocellular carcinoma (HCC) has been recommended. We conducted a matched case–control study within the US Veterans Affairs (VA) healthcare system to determine whether screening by abdominal ultrasonography (US… Continue reading
Covering the Cover
In 2 prospective cohorts, histologic grade of intestinal metaplasia before radiofrequency ablation for Barrett’s esophagus predicts recurrent neoplasia and can be used to determine surveillance intervals. Continue reading
Ceramide: A Potential Activator of Immune Responses Against Tumors
Recently, Li et al1 have reported that vein injection of nanoliposome C6-ceramide, a cell membrane permeable form of ceramide, slows growth of liver tumors in mice, through suppressing tumor-associated macrophage functions and enhancing tumor antigen-… Continue reading