Daily Archives: August 9, 2018
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We thank Drs Dai, Jiang, and Sun for their comments. We agree that assessing the risk of ischemic stroke among users of proton pump inhibitors (PPIs) with and without coadministration of clopidogrel would be worthwhile, particularly given the concern t… Continue reading
Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice via Increasing Levels of IL6R and PAI1
Combined inactivation of the microRNA 34a gene (MIR34A, by methylation) and the TP53 gene (by mutation or deletion) is observed in 50% of colorectal tumors that progress to distant metastases. We studied mice with intestinal disruption of Mir34a and Tp… Continue reading
Multiple unusual ulcerated skin lesions in a Crohn’s Disease patient
A Rare Case of Small Bowel Obstruction
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We thank Dr Risch for pointing out that our study provides important information about prediagnosis aspirin use and risk of pancreatic cancer.1 We agree that a quantitative summary of all prior studies was not undertaken as part of this analysis. The p… Continue reading
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We appreciate that Dash et al, who found our recent report1 interesting. Das note that our report does not contain information about possible autocrine production of galactin-3 from pancreatic stellate cells (PSCs) and the effects it might have on the… Continue reading