Daily Archives: August 22, 2018

Microscopic colitis is a chronic inflammatory disorder of the colon primarily affecting postmenopausal women. However, the relationship between hormonal determinants, including reproductive and menopausal factors, and risk of microscopic colitis has ye… Continue reading →

Intestinal bacteria can modify the composition of bile acids and bile acids, which are regulated by the farnesoid X receptor (FXR), affect the survival and growth of gut bacteria. We studied the effects of obeticholic acid (OCA), a bile acid analog and… Continue reading →

There is debate over the effects of long-term oral fluoroquinolone therapy in patients with advanced cirrhosis. We performed a randomized controlled trial to evaluate the effects of long-term treatment with the fluoroquinolone norfloxacin on survival o… Continue reading →

There are limited data on the risk of hepatocellular cancer (HCC) in patients with non-alcoholic fatty liver disease (NAFLD). We aimed to estimate the risk of incident HCC among patients with NAFLD. Continue reading →

Hepatitis C virus (HCV) co-opts the very low-density lipoprotein (VLDL) pathway for morphogenesis, maturation, and secretion, and circulates as lipoviroparticles (LVPs). We investigated the functions and underlying mechanisms of the lipid-associated tr… Continue reading →

Several secretagogues have been approved treatment of irritable bowel syndrome with constipation (IBS-C). However, their relative efficacy is unclear because there have been no head-to-head randomized controlled trials. We conducted a network meta-anal… Continue reading →

Growth, progression, and drug resistance of pancreatic ductal adenocarcinomas (PDACs) have been associated with increased levels and activity of glycogen synthase kinase 3 beta (GSK3B) and histone deacetylases (HCACs). We designed and synthesized molec… Continue reading →

Inactivating mutations in myosin VB (MYO5B) cause microvillus inclusion disease (MVID), but the physiological cause of the diarrhea associated with this disease is unclear. We investigated whether loss of MYO5B results in aberrant expression of apical … Continue reading →

A substantial proportion of pediatric liver transplant recipients develop subclinical chronic allograft injury. We studied whether there are distinct patterns of injury based on histopathology features and identified associated immunological profiles. Continue reading →

Mutations at hot spots in GNAS, which encodes stimulatory G-protein, alpha subunits, are detected in ∼60% of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. We generated mice with KRAS-induced IPMNs that also express a constitutivel… Continue reading →