Monthly Archives: August 2018

Human noroviruses are responsible for approximately 200,000 deaths worldwide each year. In 2012, the GII.4 Sydney strain emerged and became the major circulating norovirus strain associated with human disease. Our understanding of the human norovirus-s… Continue reading →

Despite advances in gene editing technologies, generation of tissue-specific knockout mice is time consuming. We used CRISPR/Cas9-mediated genome editing to disrupt genes in livers of adult mice in just a few months, which we refer to as somatic liver … Continue reading →

It is not clear whether we should test for reflux in patients with refractory heartburn or extra-esophageal reflux (EER) symptoms, such as cough, hoarseness, or asthma. Guidelines recommend testing patients by pH monitoring when they are on or off acid… Continue reading →

Genomic studies have revealed subtypes of pancreatic ductal adenocarcinoma (PDA) based on their molecular features, but different studies have reported different classification systems. It is a challenge to obtain high-quality, freshly frozen tissue fo… Continue reading →

Endoscopic screening for colorectal cancer (CRC) is performed at longer time intervals than the fecal occult blood test or screens for breast or prostate cancer. This causes concerns about interval cancers, which have been proposed to progress more rap… Continue reading →

We performed an integrated analysis to identify microRNAs (miRNAs) and mRNAs with altered expression in liver tumors from 3 mouse models of hepatocellular carcinoma (HCC) and human tumor tissues. Continue reading →

The increasing incidence of colorectal cancer (CRC) in younger adults (age <50 years) has been widely reported. Using data from the Surveillance, Epidemiology, and End Results Program, we young-onset CRC incidence rates decreased from 1975 through about 1990. Decreases were more prominent in the colon, a contrast with more recent increases in rectal cancer. Incidence rates subsequently increased, differing by time period and 5-year age group. This inflection point is consistent with a birth cohort effect and points to early life exposures – accumulated throughout the life course – that may increase cancer risk. Continue reading →

Most patients with esophageal adenocarcinoma (EAC) present de novo. Although this may be due to inadequate screening strategies, the precise reason for this observation is not clear.. We compared survival of patients with prevalent EAC with and without… Continue reading →