Monthly Archives: August 2018

We all want the convenience of accessing VUMC technology resources (email, calendars, eStar, and other mobile applications) on our personal mobile devices but acknowledge that this convenience comes with risks which must be addressed. (part 4 of 4 from… Continue reading →

T-cell exhaustion, or an impaired capacity to secrete cytokines and proliferate with overexpression of immune checkpoint receptors, occurs during chronic viral infections but has also been observed in tumors, including hepatocellular carcinomas (HCCs)…. Continue reading →

Microscopic colitis is a chronic inflammatory disorder of the colon primarily affecting postmenopausal women. However, the relationship between hormonal determinants, including reproductive and menopausal factors, and risk of microscopic colitis has ye… Continue reading →

Intestinal bacteria can modify the composition of bile acids and bile acids, which are regulated by the farnesoid X receptor (FXR), affect the survival and growth of gut bacteria. We studied the effects of obeticholic acid (OCA), a bile acid analog and… Continue reading →

There is debate over the effects of long-term oral fluoroquinolone therapy in patients with advanced cirrhosis. We performed a randomized controlled trial to evaluate the effects of long-term treatment with the fluoroquinolone norfloxacin on survival o… Continue reading →

There are limited data on the risk of hepatocellular cancer (HCC) in patients with non-alcoholic fatty liver disease (NAFLD). We aimed to estimate the risk of incident HCC among patients with NAFLD. Continue reading →

Hepatitis C virus (HCV) co-opts the very low-density lipoprotein (VLDL) pathway for morphogenesis, maturation, and secretion, and circulates as lipoviroparticles (LVPs). We investigated the functions and underlying mechanisms of the lipid-associated tr… Continue reading →

Several secretagogues have been approved treatment of irritable bowel syndrome with constipation (IBS-C). However, their relative efficacy is unclear because there have been no head-to-head randomized controlled trials. We conducted a network meta-anal… Continue reading →