Monthly Archives: August 2018
An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice
Growth, progression, and drug resistance of pancreatic ductal adenocarcinomas (PDACs) have been associated with increased levels and activity of glycogen synthase kinase 3 beta (GSK3B) and histone deacetylases (HCACs). We designed and synthesized molec… Continue reading
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Loss of MYO5B Leads to Reductions in Na+ Absorption with Maintenance of CFTR-dependent Cl- Secretion in Enterocytes
Inactivating mutations in myosin VB (MYO5B) cause microvillus inclusion disease (MVID), but the physiological cause of the diarrhea associated with this disease is unclear. We investigated whether loss of MYO5B results in aberrant expression of apical … Continue reading
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Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants
A substantial proportion of pediatric liver transplant recipients develop subclinical chronic allograft injury. We studied whether there are distinct patterns of injury based on histopathology features and identified associated immunological profiles. Continue reading
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GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling
Mutations at hot spots in GNAS, which encodes stimulatory G-protein, alpha subunits, are detected in ∼60% of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. We generated mice with KRAS-induced IPMNs that also express a constitutivel… Continue reading
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Concomitant gastric varices: Bleeding risk sign in patients with liver cirrhosis and esophageal varices?
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Prevalence of Advanced, Precancerous Colorectal Neoplasms in Black and White Populations: A Systematic Review and Meta-analysis
Colorectal cancer (CRC) incidence and mortality are higher in black vs white populations. The reasons for these disparities are not clear, yet some guidelines recommend screening black persons for CRC starting at ages 40–45 years. We performed a syst… Continue reading
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Post-prandial uridine physiology is altered by obesity
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Carrasco to lead Molecular Physiology and Biophysics at VU
Nancy Carrasco, MD, a leading figure in the study of iodide transport and its critical role in the thyroid and mammary glands, has been named chair of Vanderbilt University’s Department of Molecular Physiology and Biophysics. Continue reading
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VUMC IT email migration begins
VUMC IT has been managing several changes to enable the Medical Center to move to its new email and Skype for Business (Skype) environment, Microsoft Office 365. Continue reading
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VUMC mourns loss of integrative medicine pioneer Elam
Roy Elam III, MD, emeritus associate professor of Internal Medicine and founding medical director for the Osher Center for Integrative Medicine at Vanderbilt University Medical Center, died Aug. 20. He was 71. The service will be today, Thursday, Aug. … Continue reading
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