We appreciate that Dash et al, who found our recent report1 interesting. Das note that our report does not contain information about possible autocrine production of galactin-3 from pancreatic stellate cells (PSCs) and the effects it might have on the tumor microenvironment (TME). We appreciate this issue brought up by the authors. It is well-acknowledged that galectin-3 is a pleiotropic protein that is expressed and secreted by multiple cell lineages in TME as well as tumor cells. Thus galectin-3 identified in TME could be originating from tumor cells, macrophage, endothelial cells, or PSCs, as well as other immune cells.