Daily Archives: September 6, 2018

Evolving Considerations for Thiopurine Therapy for Inflammatory Bowel Diseases—a Clinical Practice Update

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Loss of Tight Junction Protein Claudin 18 Promotes Progressive Neoplasia Development in Mouse Stomach

Loss of claudin 18 (CLDN18), a membrane-spanning tight junction protein, occurs during early stages of development of gastric cancer and associates with shorter survival times of patients. We investigated whether loss of CLDN18 occurs in mice that deve… Continue reading

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“Doc, I can’t walk”—A Classic Presentation of a Rare Disease

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Efficacy and Safety of Budesonide, vs Mesalazine or Placebo, as Induction Therapy for Lymphocytic Colitis

Lymphocytic colitis is a common cause of chronic, non-bloody diarrhea. However, the effects of treatment are unclear and randomized placebo-controlled trials were requested in Cochrane review. We performed a randomized, placebo-controlled, multi-center… Continue reading

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