Daily Archives: September 19, 2018
Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors
We previously developed a tool that identified individuals who later developed esophageal adenocarcinoma (EAC; based on age, sex, body mass index, smoking status, and prior esophageal conditions) with an area under the curve of 0.80. In this study, we … Continue reading
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Earlier colorectal cancer screening may be necessary in patients with Li-Fraumeni Syndrome
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Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development
Many cell culture and animal models have been used to study hepatitis B virus (HBV) replication and its effects in the liver; these have facilitated development of strategies to control and clear chronic HBV infection. We discuss the advantages and lim… Continue reading
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Development of Direct-acting Antiviral and Host-targeting Agents for Treatment of HBV Infection
Hepatitis B virus (HBV) infection affects about 300 million people worldwide. Although antiviral therapies have improved the long-term outcomes, patients often require life-long treatment and there is no cure for HBV infection. New technologies can hel… Continue reading
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Unplanned Hospital Encounters Following Endoscopic Retrograde Cholangiopancreatography in 3 Large American States
We have few population-level data on the performance of endoscopic retrograde cholangiopancreatography (ERCP) in the United States. We investigated the numbers of unplanned hospital encounters (UHEs), patient and facility factors associated with UHEs, … Continue reading
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