Daily Archives: September 26, 2018
Hdac1 Regulates Differentiation of Bipotent Liver Progenitor Cells During Regeneration via Sox9b and Cdk8
Upon liver injury in which hepatocyte proliferation is compromised, liver progenitor cells (LPCs), derived from biliary epithelial cells (BECs), differentiate into hepatocytes. Little is known about mechanisms of LPC differentiation. We used zebrafish … Continue reading
Intestinal Inflammation and Dysregulated Immunity in Patients with Inherited Caspase-8 Deficiency
Caspase-8 (CASP8) is a protease that initiates apoptosis and regulates inflammation and immune responses. We identified germline mutations in CASP8 in 3 unrelated patients with infant-onset inflammatory bowel disease: 2 patients were homozygous for the mutation 710A>G, p.Q237R, which resulted in reduced protein expression, and 1 patient carried the mutation 793C>T, p.R265W. We isolated peripheral blood mononuclear cells from our index patient and observed defects in T- and B-cell maturation, proliferation, and/or activation. Continue reading
A complication of Crohn’s disease?
Race/Ethnicity-, Socioeconomic Status-, and Anatomic Subsite-specific Risks for Gastric Cancer
Anatomic-subsite risk factors for gastric cancer differ substantially, and subsite-specific distribution of risk factors (such as Helicobacter pylori) may vary by race/ethnicity and neighborhood socioeconomic status (nSES). We examined differences in g… Continue reading
Insights From Antiviral Therapy into Immune Responses to HBV and HCV Infection
There are 257 million persons worldwide with chronic hepatitis B virus (HBV) infection, a leading causes of liver cancer. Almost all adults with acute HBV infection have a rapid immune response to the virus resulting in life-long immunity, but there is… Continue reading