Is It Acute Pancreatitis or Recurrent Acute Pancreatitis Leading to Chronic Pancreatitis that Increases Pancreatic Cancer Risk?

We read with great interest the article by Kirkegard et al entitled, “Acute Pancreatitis and Pancreatic Cancer Risk: A Nationwide Matched-cohort Study in Denmark.”1 Our present understanding is that acute pancreatitis (AP) leads to the development of chronic pancreatitis (CP), which is associated with an increased risk of pancreatic cancer (PC). This association of CP with PC was shown by the lead author of the present study, who found that CP increases the risk of PC, but the association diminishes with long-term follow-up.

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