Anatomic-subsite risk factors for gastric cancer differ substantially, and subsite-specific distribution of risk factors (such as Helicobacter pylori) may vary by race/ethnicity and neighborhood socioeconomic status (nSES). We examined differences in gastric cancer incidence by subsite, stratified by race/ethnicity and nSES utilizing Surveillance Epidemiology and End Results Program 2000-2014 data for 77,881 incident gastric cancer cases (n=23,651 cardia, n=35,825 non-cardia; n=18,405 overlapping/unspecified).