Daily Archives: October 10, 2018
Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis
The CYLD lysine 63 deubiquitinase gene (CYLD) encodes tumor suppressor protein that is mutated in familial cylindromatosis, and variants have been associated with Crohn’s disease (CD). Splice forms of CYLD that lack exons 7 and 8 regulate transcripti… Continue reading
CME Exam 3: Association Between Magnetic Resonance Imaging-Proton Density Fat Fraction and Liver Histology Features in Patients With Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis
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We would like to thank Thevenot et al for their letter. The issue that they raise has both scientific and practical interest, specially, as the authors explain, considering that portopulmonary hypertension (PoPH) entails a high mortality and might imp… Continue reading
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We read the letter by Kountouras et al with interest. The authors comment on the findings presented in our recently published study, which provides evidence for the existence of bidirectional brain–gut interactions in patients with inflammatory bowe… Continue reading
Hepatocellular carcinoma screening: seeking robust evidence …
Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018
Estimates of disease burden can inform national health priorities for research, clinical care, and policy. We aimed to estimate health care use and spending among gastrointestinal (GI) (including luminal, liver, and pancreatic) diseases in the United S… Continue reading