Daily Archives: November 13, 2018
New app offers GPS tracking of Vanderbilt shuttles
Riders accustomed to following the progress of an Uber or Lyft ride can now have a similar experience with Vanderbilt shuttles. Passengers can now track the locations of all Vanderbilt shuttles using the Passio Go app, which is downloadable to most sma… Continue reading
Smoking rate at VUMC falls to 3.5 percent
The rate of smoking at Vanderbilt University Medical Center has dropped significantly in the past 15 years, to only 3.5 percent, down from 12.1 percent in 2003. Continue reading
Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery
Bile diversion to the ileum (GB-IL) has strikingly similar metabolic and satiating effects to Roux-en-Y gastric bypass (RYGB) in rodent obesity models. The metabolic benefits of these procedures are thought to be mediated by increased bile acids, thoug… Continue reading
Direct-acting Antiviral Therapy for HCV Infection is Associated with a Reduced Risk of Cardiovascular Disease Events
Infection with hepatitis virus C (HCV) is associated with an increased risk of cardiovascular disease (CVD) events. It is not clear whether treatment with direct-acting antiviral (DAA) agents affects risk of CVD. Continue reading
NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice
Although there are associations among oxidative stress, NADPH oxidase (NOX) activation, and hepatocellular carcinoma (HCC) development, it is not clear how NOX contributes to hepatocarcinogenesis. We studied the functions of different NOX proteins in m… Continue reading
Dexlansoprazole and Esomeprazole Do Not Affect Bone Homeostasis in Healthy Postmenopausal Women
Epidemiological studies have associated proton pump inhibitor (PPI) therapy with osteoporotic fractures, but it is not clear if PPIs directly cause osteoporosis. We evaluated the effect of dexlansoprazole and esomeprazole on bone turnover, bone mineral… Continue reading
Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups
We compared fat storage in the abdominal region among individuals from 5 different ethnic/racial groups to determine whether fat storage is associated with disparities observed in the metabolic syndrome and other obesity-associated diseases. Continue reading
Interleukin 6 receptor and inflammatory bowel disease: a Mendelian randomization study
Nuclear Translocation of RELB is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice
&Aims: Cholangiocyte proliferation and ductular reaction contribute to onset and progression of liver diseases. Little is known about the role of the transcription factor NF-kB in this process. We investigated the activities of the RELB proto-oncogene NF-kB subunit (RELB) in human cholangiocytes and in mouse models of liver disease characterized by a ductular reaction. Continue reading