Daily Archives: December 26, 2018
Moving From Current Guidelines To Personalized Colorectal Cancer Screening: Opportunities and Challenges
Plasma Cells are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease
Development of celiac disease is believed to involve the transglutaminase-dependent response of CD4+ T cells toward deamidated gluten peptides in the intestinal mucosa of individuals with specific HLA-DQ haplotypes. We investigated the antigen presenta… Continue reading
Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus
Spontaneous clearance of hepatitis C virus (HCV) occurs in approximately 30% of infected persons and less often in populations of African ancestry. Variants in major histocompatibility complex (MHC) and in interferon lambda genes are associated with sp… Continue reading
Is Elimination of Hepatitis B and C a Pipe Dream or Reality?
Due to advances in research methods, hepatitis viruses can be visualized in microscopic detail, grown in culture, and characterized fully at the genome level; hepatitis C virus (HCV) infection can be cured with drugs that block the virus’s enzymatic … Continue reading
Viral Hepatitis and Hepatocellular Carcinoma
For many decades, viral hepatitis has been an important public health threat. Hepatitis viruses infect millions of people worldwide. Chronic infections with hepatitis B virus (HBV), HCV, or HDV are associated with cirrhosis and liver cancer, and are am… Continue reading