Daily Archives: January 17, 2019

Diverticulitis is a prevalent gastrointestinal disorder that is associated with significant morbidity and health care costs. Approximately 20% of patients with incident diverticulitis have at least 1 recurrence. Complications of diverticulitis, such as… Continue reading →

Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis, the field of pancreatic genetics has made rapid progress. The identification of mutations in genes involved in the digestive protease/antiprotease pathway h… Continue reading →

Nonalcoholic fatty liver disease (NAFLD) is estimated to afflict approximately 1 billion individuals worldwide. In a subset of NAFLD patients, who have the progressive form of NAFLD termed as nonalcoholic steatohepatitis (NASH), it can progress to adva… Continue reading →

Concerns related to hepatotoxicity frequently lead to discontinuation or non-initiation of HMG-coA reductase therapy in patients with cirrhosis despite data supporting statin use. We aimed to investigate the independent effects of hyperlipidemia and st… Continue reading →

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer in the US by 2025 1, with 5-year survival at less than 10% 2. In other recalcitrant cancers, immunotherapy has shown unprecedented response rates, including dura… Continue reading →

In the previous decade, comprehensive genomic analyses have yielded important insights about the genetic alterations that underlie pancreatic tumorigenesis. Whole exome and whole genome sequencing of pancreatic ductal adenocarcinomas have confirmed the… Continue reading →

There is controversy over the effects of direct-acting antiviral (DAA) therapies for hepatitis C (HCV) infection on hepatocellular carcinoma (HCC) recurrence and tumor aggressiveness. We compared HCC recurrence patterns between DAA-treated and untreate… Continue reading →