Monthly Archives: January 2019
Genetics and pathophysiology of pancreatitis
Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis, the field of pancreatic genetics has made rapid progress. The identification of mutations in genes involved in the digestive protease/antiprotease pathway h… Continue reading
Non-Invasive Assessment of Liver Disease in Patients with NAFLD
Nonalcoholic fatty liver disease (NAFLD) is estimated to afflict approximately 1 billion individuals worldwide. In a subset of NAFLD patients, who have the progressive form of NAFLD termed as nonalcoholic steatohepatitis (NASH), it can progress to adva… Continue reading
Evolving Trends in Machine Perfusion for Liver Transplantation
Effects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis
Concerns related to hepatotoxicity frequently lead to discontinuation or non-initiation of HMG-coA reductase therapy in patients with cirrhosis despite data supporting statin use. We aimed to investigate the independent effects of hyperlipidemia and st… Continue reading
Broadening the impact of immunotherapy to pancreatic cancer: Challenges and opportunities
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer in the US by 2025 1, with 5-year survival at less than 10% 2. In other recalcitrant cancers, immunotherapy has shown unprecedented response rates, including dura… Continue reading
Acute pancreatitis: a multi-faceted set of organellar andcellular interactions
Genetics of Familial and Sporadic Pancreatic Cancer
In the previous decade, comprehensive genomic analyses have yielded important insights about the genetic alterations that underlie pancreatic tumorigenesis. Whole exome and whole genome sequencing of pancreatic ductal adenocarcinomas have confirmed the… Continue reading
Direct-Acting Antiviral Therapy not Associated with Recurrence of Hepatocellular Carcinoma in a Multicenter North American Cohort Study
There is controversy over the effects of direct-acting antiviral (DAA) therapies for hepatitis C (HCV) infection on hepatocellular carcinoma (HCC) recurrence and tumor aggressiveness. We compared HCC recurrence patterns between DAA-treated and untreate… Continue reading
Mizagliflozin for the Treatment of Functional Constipation: Are New Drugs Better?
Fukudo S, Endo Y, Hongo M et al. Safety and efficacy of the sodium-glucose cotransporter 1 inhibitor mizagliflozin for functional constipation: a randomized, placebo-controlled, double-blind phase 2 trial. Lancet Gastroenterol Hepatol 2018;3:603–613. Continue reading
Insights into How Probiotics Colonize the Healthy Human Gut
Zmora N, Zilberman-Schapira G, Suez J, et al. Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features. Cell 2018;174:1388–1405. Continue reading